The mega-corporate Daedalus Group is under attack by a small group of activists known as the Ghost of Icarus. While taking care of some of the victims of the bombing, Black Jack encounters Dr. Kiriko, also known as Death Incarnate, who just like him, asks his patients huge sums of money but instead of saving them, he offers them a painless death. When the activist group requests both doctors’ collaboration, Black Jack finds himself caught in a spiral of life, death and treason while trying to save his patients' lives and avoid the breaking of a biological war that could destroy humanity.

Pinoko saves Sharaku from Kong, a bully, and they become friends. Then, Sharaku becomes sick and Black Jack operates on him, but a runaway gurney causes an IV needle to break off in his vein. Black Jack fails to extract the needle, but by a miracle it comes out on its own.

Black Jack spots Mitsuo, a boy in a wheelchair, intently reading a book called "The Records of a Disabled Person," in a coffee shop. A few days later, Mitsuo sets off from the square, carrying out a plan to walk from Hiroshima to Osaka to rehabilitate his disabled leg and challenge himself. The walk is broadcast on television, and Mitsuo can be seen on the TV in Black Jack's living room. That evening, Black Jack leaves his house, wanting to travel alone. As Mitsuo walks along the national highway and approaches a hill, Black Jack appears from a parked car...