The popular Osomatsu brothers are now back?! However, times have changed and the sextuplets try to figure out the best way to come back that will appeal to the current TV audience...

The sextuplets attempt to find a job, and Osomatsu tries to find where all of his brothers went off to.

This week's episode is the tidbits collection. Everything from Dekapan-man, to what happens if you try to horde your pachinko winnings, to a bath house quiz.

Choromatsu is worried that his brothers are depending too much on their parents.

Karamatsu is taken hostage and demands the Matsuno brothers pay off their tab for his oden stand.

The Matsunos are invited to Hatabou's birthday party, becoming surprised to discover he is living the rich life.

Todomatsu faces the biggest threat to his social life when his brothers show up at his workplace just as his co-workers are about to invite him to a mixer.

Osomatsu plays as a detective who calms down people working on murder cases with his buffoonery instead of actually solving them.

While discussing his career plans, Karamatsu somehow winds up as Chibita's apprentice at his oden stand.

Looking to earn some easy money, Iyami and Chibita set up their own "Rental Girlfriend" business, which gets no business due to how ugly they look.

A series of Christmas-themed skits. Ichimatsu takes on the role of a Black Santa interrupting a romantic couple's date, while Karamatsu finds himself on a date with an unfortunate ending.

Recap episode. Osomatsu and Totoko host an end-of-the-year special broadcast, looking back on previous episodes.

This episode features a down-on-his-luck salaryman named Sanematsu who faces hardships from his co-workers, and imaginary sextuplet brothers. Also, genderbent versions of the Matsuno siblings argue with each other over guys.

The brothers all catch colds, with whoever's left healthy causing a lot of trouble while trying to take care of the others.

Jyushimatsu goes to a job interview, proving to be a total nuisance for the interviewers, while the Girlymatsu sisters try to pass the time while on vacation.

In a post-apocalyptic world, the Idol Matsunos battle against Iyami and Dekapan, who are robbing the dry-skinned citizens of all of their lotion.

A series of skits all revolving around Jyushimatsu's odd personality as well as the brothers' view on him.

Wanting to become the main protagonist of the franchise again, Iyami holds a bizarre kart race to determine who the protagonist of Osomatsu-san will be.

The concept of a Hijirisawa Shōnosuke-san anime quickly gets dropped due to lack of ideas, replaced with a series of skits set during the Sengoku era.

Kicked out of his own company, Hatabou starts his own catering service in order to regain his fortune, leaving the Matsuno siblings curious about what meat he has been using.

On a rainy evening, the brothers play a game of mahjong, with each brother showing his own strengths and glaring weaknesses.

Todomatsu holds auditions to take one of his brothers with him to a mixer, struggling to find anyone worth taking.

When the family heater runs out of kerosene, the brothers find themselves in an underground village populated by a tribe of Dayon people.

Totoko experiences jealousy for the first time after people start getting more success than her, leading her on a quest to find an oil magnate to marry.

The brothers quickly abandon their new lifestyles upon learning they have been invited to a baseball tournament. After failing miserably the first time, the family soon grow stronger and reach the final round of the next tournament. Facing off against a ruthless team of aliens that murder the rest of their team, the brothers are spurned on by the chance to lose their virginities, but end up losing anyway.