Ten years ago, young Integra Hellsing ascends to the head of the Hellsing Organization after the death of her father Arthur. Her jealous uncle Richard Hellsing attempts to kill her, but in doing so awakens a dormant Alucard, who proceeds to kill Richard`s men. It is Integra who shoots and kills her uncle, thereby becoming the last descendant of the Hellsing bloodline. Alucard declares his allegiance to Integra and becomes her loyal servant. In present day England, Alucard is called to duty to eradicate a vampire priest and his ghouls. However, a police girl named Seras Victoria is gravely injured in the process, and upon giving her a choice to live or die, Alucard turns her into his vampire servant. Later, on a mission to hunt down a vampire in the town of Badrick in Northern Ireland, Alucard meets and fights Father Alexander Anderson for the first time.

Two daring vampire brothers lead a violent raid on the Hellsing compound. The carnage is great, but Alucard and company manage to gain a key piece of information while turning the battle’s tide.

The Hellsing organization resorts to the recruitment of mercenaries in the wake of a devastating attack on headquarters, and Integra’s suspicions concerning the origins of their enemy are confirmed.

An important meeting between Hellsing and the Queen is interrupted by tidings of impending war. Meanwhile, Alucard is sent to deal with the deviants responsible for the hijacking of an aircraft carrier.

While Alucard is trapped aboard an aircraft carrier, London is plagued by a gruesome vampire onslaught. Elsewhere, Integra narrowly escapes a horde of Nazi vampires.

The Vatican’s formidable combat unit is mobilized in preparation for battle. Back in the heart of London, the Hellsing Mansion is attacked, and the Wild Geese represent the last line of defense against the undead.

When her memories are violated, Seras becomes trapped in an illusion which forces her to relive the most horrifying moments of her life. Upon waking from the nightmare, the real pain begins as the battle nears its end.

The harrowing conclusion to Hellsing Ultimate features the epic return of Alucard and Integra’s willingness to unleash his true power on their enemies!

Alucard faces off with father Anderson. Meanwhile, the Major starts to put his last parts of his plan into motion.

And now an ending. London is in ruins, Enrico's crusade has failed, captain Bernadotte and Alexander Anderson has fallen and Walter has defected to Millenium. As Alucard duels Walter, Seras and Integra fights through the zeppelin Deus Ec Machina and faces the last remaining soldiers of Millenium. But there also waits the leaders of Millenium: the Major and the mysterious Captain, the man Walter feared to face and who is about to reveal his true nature...